single-cell RNA sequencing

[Nature Neuroscience] Researchers reported the development of a cerebral organoid slice model derived from human induced pluripotent stem cells that recapitulated mature cortical architecture and displayed early molecular pathology of C9ORF72 ALS/FTD.

[Theranostics] Lung cancer patient-derived cancer cell and cancer-associated fibroblasts were utilized to mimic the tumor microenvironment and reproduced the stemness properties of cancer stem cells in vitro and developed a high-throughput drug screening platform with phenotypical parameters.

[Oncogene] To identify clinically relevant microenvironmental and cancer features, scientists applied single-cell RNA sequencing to ten human lung adenocarcinomas and ten normal control tissues.

[NPJ Genomic Medicine] Scientists performed single-cell RNA-sequencing analysis using Fluidigm C1 systems to characterize human lung cancer transcriptomes at single-cell resolution.

[Circulation Research] Researchers assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload-induced by transverse aortic constriction.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers examined the immune cell profile of eight cell suspension samples of Lymphocyte-rich classic Hodgkin lymphoma (LR-CHL) in comparison to 20 samples of the mixed cellularity and nodular sclerosis subtypes of CHL.