smooth muscle cells

[iScience] Scientists showed that vascular smooth muscle cells (VSMCs) in brains of Alzheimer’s disease patients and animal models of the disease were deficient in multiple VSMC-contractile markers which correlated with the Tau accumulation in brain arterioles.

[Nature Biomedical Engineering] Investigators reported the reprogramming of mouse tail-tip fibroblasts simultaneously into cells resembling cardiomyocytes, endothelial cells or smooth muscle cells using the microRNA mimic miR-208b-3p, ascorbic acid and bone morphogenetic protein 4, as well as the formation of tissue-like structures formed by the directly reprogrammed cells.

[Biology Open] Large clones were found between cartilage and smooth muscle where subpopulation of dorsal basal cells (BCs) existed. 3D organoid culture of BCs demonstrated that dorsal BCs showed higher colony forming efficacy to ventral BCs.

[Bioscience Reports] The authors bring together emerging understanding of basement membrane defects within the heart including in common cardiovascular pathologies such as contractile dysfunction and highlight some key questions that are now ready to be addressed.

[Nature Communications] Researchers showed that differentiating human iPSC-derived lateral plate mesoderm with BMP4, RA and VEGF could generate a premature form of epicardial cells expressing WT1, TBX18, SEMA3D, and SCX within 7 days.

[Molecular Medicine Reports] Human vascular smooth muscle cells were loaded with cholesterol and different concentrations of metformin. The expression levels of adhesion molecules were assessed via reverse transcription‑quantitative PCR and western blotting.