TGFβ

[Journal of Biomedical Science] Emphasis is given to the role that leucine-rich α-2 glycoprotein 1 (LRG1) plays as a vasculopathic factor where it disrupts the cellular interactions normally required for the formation and maintenance of mature vessels, thereby indirectly contributing to the establishment of a highly hypoxic and immunosuppressive microenvironment.

[Oncogene] The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.

[Theranostics] Wnt signaling was activated by the overexpression of Lrp5 and β-catenin in osteoblasts as well as a pharmacological agent and the therapeutic effects of their conditioned medium were evaluated using in vitro cell cultures, ex vivo breast cancer tissues, and a mouse model of osteolysis.

[Nature Review Cardiology] The author summarizes the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discussing challenges and opportunities for therapeutic translation.

[Nature Reviews Cardiology] The authors summarize the current evidence on the role of TGFβ signaling in myocardial diseases, focusing on cellular targets and molecular mechanisms, and discuss challenges and opportunities for therapeutic translation.

[Cancer Research] Using genetically defined models, researchers showed that HDAC2 was a cellular fitness factor that controls cell cycle in vitro and metastasis in vivo, particularly in undifferentiated, mesenchymal pancreatic ductal adenocarcinoma cells.