TNF-α

[Oxidative Medicine and Cellular Longevity] In order to discover novel endothelial-specific receptor tyrosine kinases (VEGFR)-2 TK inhibitors, scientists designed and synthesized three new series of pyridine-containing compounds. The new compounds were all screened against a panel of three cell lines.

[Journal of Experimental Medicine] Researchers observed that neutrophil DREAM repressed expression of A20, a negative regulator of NF-κB activity, and enhanced expression of pro-inflammatory molecules and phosphorylation of IκB kinase after TNF-α stimulation.

[Cell Death Discovery] The authors investigated the effects of wild-type p53-induce phosphatase 1 (Wip1) on regulating MSCs immunosuppressive capacities in type 1 diabetes mellitus mice.

[Laboratory Investigation] Researchers demonstrated marked and synergistic upregulation of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 4 by IL-1α, TNF-α and TGF-β in osteoarthritis (OA) synovial fibroblasts, and suggested that concurrent therapy with an anti-TNF-α drug and inhibitor may be useful for prevention against aggrecan degradation in OA.

[Cell Death & Disease] The authors investigated a previously unrecognized role for ferroptosis in psoriasis, where ferroptosis was mediated by lipid peroxidation and iron overload. They found that ferrostatin-1 blocked inflammatory responses in vitro and in vivo, which reduced cytokine production.

[Brain Research Bulletin] An intracerebral hemorrhage (ICH) model was established by injecting autologous blood into the right basal ganglia of Sprague-Dawley rats. After ICH induction, the protein levels of Krüppel-like transcription factor 2 were reduced.