TNF-α

[EMBO Molecular Medicine] The authors employed gene transfer into hematopoietic stem and progenitor cells to selectively express anti-tumoral cytokines in tumor-infiltrating monocytes/macrophages.

[Thrombosis and Haemostasis] Utilizing stasis-induced murine deep vein thrombosis model and cultured endothelial cells, scientists identified an increase of KLF11 expression under prothrombotic conditions both in vivo and in vitro.

[International Archives of Allergy and Immunology] Cough-variant asthma (CVA) is a special type of asthma, solely manifesting with coughing. Investigators suggested that airway inflammation was associated with CVA pathogenesis.

[Acta Pharmacologica Sinica] Researchers found that ethyl ferulate significantly alleviated lipopolysaccharide-induced pathological damage and neutrophil infiltration and inhibited the gene expression of proinflammatory cytokines in murine lung tissues.

[Scientific Reports] Investigators reported Mangiferin functionalized gold nanoparticulate agent and its immunomodulatory characteristics in treating prostate cancer.

[Pediatric Research] Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.