TNF-α

[Signal Transduction and Targeted Therapy] Scientists demonstrated that the expression of KLF2 was reduced and monocyte adhesion was increased in endothelial cells treated with COVID-19 patient serum due to elevated levels of pro-adhesive molecules, ICAM1 and VCAM1.

[Signal Transduction and Targeted Therapy] Scientists discuss the initiation and resolution of inflammation, the crosstalk between tumor development and inflammatory processes.

[Food Chemistry] The authors co-fermented collagen peptide-jackfruit juice was used in immunosuppressed mice to evaluate the immune response and gut microbiota modulatoration.

[International Immunopharmacology] Scientists showed that TNF-α significantly reduced the expression of SIRT6 protein and mRNA in a concentration- and time-dependent manner and increased the expression of monocyte chemotactic protein 1, interleukin (IL) -6 and IL-1β in human umbilical vein endothelial cells.

[Nature Communications] Researchers showed that in vitro treatment of cytotoxic T lymphocytes and CAR T cells with pentanoate and butyrate increases the function of mTOR as a central cellular metabolic sensor, and inhibits class I histone deacetylase activity.

[Scientific Reports] Fenofibrate reduced IEL density in the duodenum of dogs with diabetes mellitus and enhanced markers of intestinal barrier function in vivo and in vitro.