triple negative breast cancer

[Oncogene] Scientists discovered an intrinsic signaling scaffold function of THEMIS2, which acted as a novel regulator of cancer stemness in promoting multiple cancer stemness properties including sphere formation, stemness markers expression, chemoresistance and tumorigenicity with low numbers of cancer cells implantation.

[Tissue Engineering and Regenerative Medicine] Researchers reported a novel strategy to generate highly pure mouse bone marrow MSCs using liposomal clodronate.

[Nature Communications] Using two independent TNBC models, the authors reported a discrete subpopulation of highly metastatic SOX2/OCT4+ cells within primary tumors that exhibitrf elevated intracellular copper levels and a marked sensitivity to tetrathiomolybdate.

[Cancer Research] Cell lines grown in vivo more faithfully recapitulated the metabolic profiles of patient tumors compared to those grown in vitro. Integrated metabolic and gene expression analyses identified genes that strongly correlated with metabolic dysregulation and predicted patient prognosis.

[Molecular Cancer Research] Scientists demonstrated that overexpression of G protein–coupled receptors implicated in breast cancer pathogenesis, specifically the receptors for Angiotensin II and thrombin, drove a strong epithelial-to-mesenchymal transition program in breast cancer cells that was characteristic of claudin-low, TNBC.

[Cell Death & Disease] The authors identified high NOXA/PMAIP mRNA expression levels as an independent prognostic marker for improved relapse-free survival and overall survival in multivariate analysis in breast cancer patients, independent of their molecular subtype.