tubular epithelial cells

[Cell Reports] Signal transduction and activator of transcription 3 (STAT3) activation increased migration and profibrotic signaling in genome-edited, pericyte-like cells. Conversely, blocking Stat3 inhibited detachment, migration, and profibrotic signaling.

[Clinical Science] The authors described a novel feedback loop composed of histone deacetylase 2 (HDAC2) and miR-205 that regulated ECM production in tubular epithelial cells in individuals with diabetic kidney disease.

[Journal of the American Society of Nephrology] Scientists explore the mechanisms and detection of acute kidney injury in tissue culture, with an emphasis on bioengineered approaches such as human kidney organoid models.

[Human & Experimental Toxicology] Lysine-specific demethylase 1 significantly impacted on the progression of TGF-β1-mediated epithelial-mesenchymal transition and ECM deposition in HK-2 cells, and it may represent novel target for the prevention strategies of renal fibrosis.

[Free Radical Biology and Medicine] Western blot analysis, flow cytometry, and MitoSOX staining revealed that hyperglycemia-induced mitochondrial oxidative stress production and apoptosis were attenuated in CHIP-overexpressing Wharton's jelly-derived mesenchymal stem cells

[Cell Death & Disease] In vitro, TGF-β1 treatment augmented glycogen synthase kinase 3β expression in tubular epithelial cells, concomitant with dedifferentiation, cell cycle arrest at G2/M phase, excessive accumulation of extracellular matrix, and overproduction of profibrotic cytokines like PAI-1 and CTGF.