Permissive Effect of GSK3β on Profibrogenic Plasticity of Renal Tubular Cells in Progressive Chronic Kidney Disease

In vitro, TGF-β1 treatment augmented glycogen synthase kinase 3β expression in tubular epithelial cells, concomitant with dedifferentiation, cell cycle arrest at G2/M phase, excessive accumulation of extracellular matrix, and overproduction of profibrotic cytokines like PAI-1 and CTGF.
[Cell Death & Disease]
Chen, B., Wang, P., Liang, X., Jiang, C., Ge, Y., Dworkin, L. D., & Gong, R. (2021). Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease. Cell Death & Disease, 12(5), 1–14. https://doi.org/10.1038/s41419-021-03709-5 Cite
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Loss of Endothelial Glucocorticoid Receptor Accelerates Diabetic Nephropathy

The fibrogenic phenotype in the kidneys of diabetic mice lacking endothelial glucocorticoid receptor was associated with aberrant cytokine and chemokine reprogramming, augmented Wnt signaling and suppression of fatty acid oxidation.
[Nature Communications]
Srivastava, S. P., Zhou, H., Setia, O., Liu, B., Kanasaki, K., Koya, D., Dardik, A., Fernandez-Hernando, C., & Goodwin, J. (2021). Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy. Nature Communications, 12(1), 2368. https://doi.org/10.1038/s41467-021-22617-y Cite
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Endothelial SIRT3 Regulates Myofibroblast Metabolic Shifts in Diabetic Kidneys

Researchers found that endothelial SIRT3 regulated metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice.
[iScience]
Srivastava, S. P., Li, J., Takagaki, Y., Kitada, M., Goodwin, J., Kanasaki, K., & Koya, D. (2021). Endothelial SIRT3 regulates myofibroblast metabolic shifts in diabetic kidneys. IScience, 0(0). https://doi.org/10.1016/j.isci.2021.102390 Cite
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Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection

Membrane nanoparticles prepared from ACE2-rich cells were discovered to have potent capacity to block SARS-CoV-2 infection.
[ACS Nano]
Wang, C., Wang, S., Chen, Y., Zhao, J., Han, S., Zhao, G., Kang, J., Liu, Y., Wang, L., Wang, X., Xu, Y., Wang, S., Huang, Y., Wang, J., & Zhao, J. (2021). Membrane Nanoparticles Derived from ACE2-Rich Cells Block SARS-CoV-2 Infection. ACS Nano. https://doi.org/10.1021/acsnano.0c06836 Cite
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Comprehensive Metabolomic Study of the Response of HK-2 Cells to Hyperglycemic Hypoxic Diabetic-Like Milieu

A comprehensive metabolomic study of the response of HK-2 cells, a human cell line derived from normal proximal tubular epithelial cells, to hyperglycemic, hypoxic diabetic-like milieu has been performed.
[Scientific Reports]
Valdés, A., Lucio-Cazaña, F. J., Castro-Puyana, M., García-Pastor, C., Fiehn, O., & Marina, M. L. (2021). Comprehensive metabolomic study of the response of HK-2 cells to hyperglycemic hypoxic diabetic-like milieu. Scientific Reports, 11(1), 5058. https://doi.org/10.1038/s41598-021-84590-2 Cite
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Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p

Lentivirus-mediated overexpression, as well as antisense oligonucleotide-based silencing, modulated H19 in vitro. In vivo analyses used constitutive H19 knockout mice.
[Journal of the American Society of Nephrology]
Haddad, G., Kölling, M., Wegmann, U. A., Dettling, A., Seeger, H., Schmitt, R., Soerensen-Zender, I., Haller, H., Kistler, A. D., Dueck, A., Engelhardt, S., Thum, T., Mueller, T. F., Wüthrich, R. P., & Lorenzen, J. M. (2021). Renal AAV2-Mediated Overexpression of Long Non-Coding RNA H19 Attenuates Ischemic Acute Kidney Injury Through Sponging of microRNA-30a-5p. Journal of the American Society of Nephrology. https://doi.org/10.1681/ASN.2020060775 Cite
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WNT–β-Catenin Signaling – A Versatile Player in Kidney Injury and Repair

WNT–β-catenin signaling is involved in chronic kidney disease-associated vascular calcification and mineral bone disease. The WNT–β-catenin pathway is tightly regulated, for example, by proteins of the Dickkopf family.
[Nature Reviews Nephrology]
Schunk, S. J., Floege, J., Fliser, D., & Speer, T. (2020). WNT–β-catenin signalling — a versatile player in kidney injury and repair. Nature Reviews Nephrology, 1–13. https://doi.org/10.1038/s41581-020-00343-w Cite
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Extracellular Vesicle–Encapsulated IL-10 as Novel Nanotherapeutics against Ischemic AKI

Treatment with IL-10+ extracellular vesicles significantly ameliorated renal tubular injury and inflammation caused by ischemia/reperfusion injury, and potently prevented the transition to chronic kidney disease.
[Science Advances]
Tang, T.-T., Wang, B., Wu, M., Li, Z.-L., Feng, Y., Cao, J.-Y., Yin, D., Liu, H., Tang, R.-N., Crowley, S. D., Lv, L.-L., & Liu, B.-C. (2020). Extracellular vesicle–encapsulated IL-10 as novel nanotherapeutics against ischemic AKI. Science Advances, 6(33), eaaz0748. https://doi.org/10.1126/sciadv.aaz0748 Cite
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Human Umbilical Cord-Derived Mesenchymal Stem Cells Prevent the Progression of Early Diabetic Nephropathy through Inhibiting Inflammation and Fibrosis

Scientists identified the basic biological properties and examined the multilineage differentiation potential of umbilical cord-MSCs.
[Stem Cell Research & Therapy]
Xiang, E., Han, B., Zhang, Q., Rao, W., Wang, Z., Chang, C., Zhang, Y., Tu, C., Li, C., & Wu, D. (2020). Human umbilical cord-derived mesenchymal stem cells prevent the progression of early diabetic nephropathy through inhibiting inflammation and fibrosis. Stem Cell Research & Therapy, 11(1), 336. https://doi.org/10.1186/s13287-020-01852-y Cite
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