Lysine-Specific Demethylase 1 Induced Epithelial-Mesenchymal Transition and Promoted Renal Fibrosis through Jagged-1/Notch Signaling Pathway

Lysine-specific demethylase 1 significantly impacted on the progression of TGF-β1-mediated epithelial-mesenchymal transition and ECM deposition in HK-2 cells, and it may represent novel target for the prevention strategies of renal fibrosis.