tubular epithelial cells

[Nature Communications] The fibrogenic phenotype in the kidneys of diabetic mice lacking endothelial glucocorticoid receptor was associated with aberrant cytokine and chemokine reprogramming, augmented Wnt signaling and suppression of fatty acid oxidation.

[iScience] Researchers found that endothelial SIRT3 regulated metabolic reprogramming and fibrogenesis in the kidneys of diabetic mice.

[ACS Nano] Membrane nanoparticles prepared from ACE2-rich cells were discovered to have potent capacity to block SARS-CoV-2 infection.

[Scientific Reports] A comprehensive metabolomic study of the response of HK-2 cells, a human cell line derived from normal proximal tubular epithelial cells, to hyperglycemic, hypoxic diabetic-like milieu has been performed.

[Journal of the American Society of Nephrology] Lentivirus-mediated overexpression, as well as antisense oligonucleotide-based silencing, modulated H19 in vitro. In vivo analyses used constitutive H19 knockout mice.

[Nature Reviews Nephrology] WNT–β-catenin signaling is involved in chronic kidney disease-associated vascular calcification and mineral bone disease. The WNT–β-catenin pathway is tightly regulated, for example, by proteins of the Dickkopf family.