The fibrogenic phenotype in the kidneys of diabetic mice lacking endothelial glucocorticoid receptor was associated with aberrant cytokine and chemokine reprogramming, augmented Wnt signaling and suppression of fatty acid oxidation.
[Nature Communications]
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Srivastava, S. P., Zhou, H., Setia, O., Liu, B., Kanasaki, K., Koya, D., Dardik, A., Fernandez-Hernando, C., & Goodwin, J. (2021). Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy. Nature Communications, 12(1), 2368. https://doi.org/10.1038/s41467-021-22617-y Cite