tumor-infiltrating lymphocytes

[Cancer Cell] Investigators showed that tumor-specific CD8+ tumor-infiltrating lymphocytes accumulated in tumor islets, where they engage antigen and upregulate PD-1, which restrained their functions.

[Breast Cancer Research and Treatment] The authors examine the role of immune-activating cells, including tumour-infiltrating lymphocytes, and natural killer cells, as well as immune inhibitory cells, including T regulatory cells, and myeloid-derived suppressor cells in the breast cancer tumour microenvironment.

[Nature Communications] Hypothesizing that EGFR mutations alter tumor-immune interactions, scientists compared tumor-infiltrating lymphocytes between EGFR mutant and wild type tumors through single-cell transcriptomic analysis.

[Breast Cancer Research] Scientists investigated the effect of oestrogen deprivation on the expression of chemokines and immune infiltration in vitro and in an ER+ immunocompetent mouse model.

[Nanoscale] The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. Effector OT-1 CD8+T cells conjugated with liposomal immune regulators were developed to address this issue.

[Scientific Reports] 42.8% of patients who exhibited significantly higher immunocyte infiltration and enrichment of immune response-associated signatures were subdivided into immune classes.