Publication

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers revealed that the Kaposi's sarcoma-associated herpesvirus ORF37-encoded SOX protein suppressed AIM2 inflammasome activation independent of its viral DNA exonuclease activity and host mRNA turnover.

[Microbiology Spectrum] Scientists examined the impact of CD8+ cell depletion by monoclonal anti-CD8 antibody administration on proviral load in human T cell leukemia virus type 1 (HTLV-1)-infected cynomolgus macaques.

[Scientific Reports] The authors characterized the transcriptomic and genomic mutation profiles of canine soft tissue sarcomas subtypes, by leveraging RNAseq, whole exome sequencing, immunohistochemistry, and drug assays.

[Cell Communication And Signaling] Scientists found that the population and migration ability of bone marrow MSCs from adiponectin KO mice was higher than that of WT mice due to increased stability of hypoxia inducible factor 1α.

[Breast Cancer Research And Treatment] The authors analyzed clinical outcomes with elacestrant, compared with endocrine therapy, among women who had previously been treated with a fulvestrant-containing regimen from the recent Phase III EMERALD Study.

[Signal Transduction And Targeted Therapy] Scientists explored the influence of ECM-derived biomechanical force on breast cancer cell status. Experiments were conducted using 3D collagen, fibrinogen, and Matrigel matrices to investigate the role of mechanical force in tumor development.