Publication

[Cell Death & Disease] Scientists found that receptor interacting protein kinase 1 (RIPK1)-dependent necroptosis promoted vasculogenic mimicry (VM) formation in TNBC. Knockdown of RIPK1 significantly suppressed the number of necroptotic cells and VM formation.

[Oncogene] Researchers reported that ZNF133, a zinc-finger protein, was negatively associated with poor survival and advanced pathological staging of breast carcinomas. Moreover, ZNF133 was a transcription repressor physically associated with the KAP1 complex.

[Frontiers In Oncology] Expression of bone morphogenetic protein (BMP), BMP receptors, and antagonists in breast cancer were analyzed by using TCGA-BRCA and E-MTAB-6703 cohorts.

[Endocrinology] To understand the mechanisms of p-Ser134-GR action in the presence of glucocorticoid receptor (GR) agonists, the authors examined glucocorticoid-driven transcriptomes in CRISPR knock-in models of TNBC cells expressing wild-type or phospho-mutant GR.

[Scientific Reports] Scientists showed that Adenosine Deaminase Acting on RNA 1 (ADAR1) was more abundantly expressed in infiltrating breast cancer (BC) tumors than in benign tumors. Further, ADAR1 protein expression was higher in aggressive BC cells.

[Scientific Reports] Researchers investigated the molecular mechanism of miR-183 in breast cancer. Phosphatase and tensin homolog (PTEN) was validated by dual luciferase assay as a target gene of miR-183. Through qRT-PCR analysis, miR-183 and PTEN mRNA levels in breast cancer cell lines were measured.