Publication

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Researchers showed that hepatocyte-restricted expression of a single chain c-Jun~Fra-2 protein, which functionally mimiced the c-Jun/Fra-2 AP-1 dimer, resulted in spontaneous HCC formation in c-Jun~Fra-2hep mice.

[Journal Of Clinical Investigation] Scientists developed a mouse model of sedentariness, small mouse cage that, unlike other classic models of disuse in mice, faithfully recapitulated metabolic responses that occured in humans.

[New England Journal Of Medicine] The authors conducted an open-label, single-group, Phase III study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β0/β0, β0/β0-like, or non–β0/β0-like genotype.

[Cancer Cell] Investigators reported that p53 was activated following BH3-mimetic induced mitochondrial outer membrane permeabilization, leading to BH3-only protein induction and thereby potentiating the pro-apoptotic signal.

[EMBO Reports] Researchers examined mESC lines with an inducible Xist allele and integrated allele-specific data of gene silencing and decreasing inactive X chromatin accessibility over time courses of Xist induction with cellular differentiation.

[Nucleic Acids Research] Scientists presented a precise and programmable method called prime editor–mediated correction of nucleotide repeat expansion for correcting pathogenic nucleotide repeat expansion.