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Biomimetic Lung-Targeting Nanoparticles with Antioxidative and Nrf2 Activating Properties for Treating Ischemia/Reperfusion-Induced Acute Lung Injury

[Nano Letters] The authors developed a biomimetic lung-targeting nanoparticle as an antioxidative lung protector for treating ischemia/reperfusion-induced acute lung injury.

Alcohol and E-Cigarette Damage Alveolar-Epithelial Barrier by Activation of P2X7r and Provoke Brain Endothelial Injury via Extracellular Vesicles

[Cell Communication And Signaling] Investigators used a model of primary human pulmonary alveolar epithelial cells and exposed the cells to 100 mM ethanol, 100 µM acetaldehyde, or e-Cig conditioned media, and measured the mitochondrial efficiency using Agilent Seahorse machine.

Multiscale Spatial Mapping of Cell Populations Across Anatomical Sites in Healthy Human Skin and Basal Cell Carcinoma

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators reported a comprehensive spatial atlas of adult human skin across different anatomical sites and basal cell carcinoma — the most common form of skin cancer—encompassing in vivo optical coherence tomography, scRNAseq, global spatial transcriptomic profiling, and in situ sequencing.

Association Between Clonal Hematopoiesis Driver Mutations, Immune Cell Function, and the Vasculometabolic Complications of Obesity

[Journal Of The American Heart Association] 297 individuals with overweight and obesity, between the ages of 54 and 81 years, were recruited in a cross‐sectional study. Clonal hematopoiesis driver mutations were identified with an ultrasensitive targeted assay.

ZBP1 Activation Triggers Hematopoietic Stem and Progenitor Cell Death Resulting in Bone Marrow Failure in Mice

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists demonstrated that similar to a RIPK3 deficiency, an MLKL deficiency significantly extended survival and like Ripk3 deficiency partially restored hematopoiesis in Ripk1HEM KO mice revealing that both necroptosis and apoptosis contribute to bone marrow failure in these mice.

Bridging Tissue Repair and Epithelial Carcinogenesis: Epigenetic Memory and Field Cancerization

[Cell Death & Differentiation] Scientists review the similarities between tissue repair and carcinogenesis, with a special focus on the epigenetic mechanisms activated by cells during repair and opted by carcinoma cells in multiple epithelia.

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