Publication

[Journal Of Immunology] Researchers demonstrate that CD2 expression on CX3CR1+CD57+CD28− inflammescent CD8 T cells is increased on cells from cytomegalovirus-seropositive people with HIV. In vitro CD2/LFA-3 costimulation enhances TCR-mediated activation of these inflammatory CD8 memory T cells.

[Human Vaccines & Immunotherapeutics] Investigators described the humoral and cell-mediated immune responses in 38 cancer patients treated with immune checkpoint inhibitors and receiving the glycoprotein E-based recombinant vaccine.

[International Journal Of Oral Science] Scientists investigated the effects of apoptotic bodies (ABs) derived from MSCs on periodontitis. MSCs were derived from bone marrows of mice and were cultured under hypoxic conditions for 72 h, after which ABs were isolated from the culture supernatant using a multi-filtration system.

[Cell Death & Disease] Researchers evaluated the methyltransferase-like 3 (METTL3) function in vivo. Mice exhibiting a conditional removal of Mettl3 in bone marrow MSCs were developed by mating Prrx1-CreERT2;Mettl3fl/+ mice with Mettl3fl/fl mice using the CRISPR-Cas9 system.

[Small] Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.

[Translational Oncology] Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cell from NF1 were isolated and cultured using fluorescence activated cell sorting and colony formation experiments.