Review

[Medical Oncology] In-depth identification of tumor microenvironment and development of more potent CAR platform targeting CSCs may overcome the raised challenges, as presented in this review.

[New England Journal Of Medicine] Stem cells can renew themselves without differentiating. Aging, inflammation, and environmental exposures may drive phenotypic changes in tissue stem cells that cause them to become CSCs.

[Small] The authors introduce the biological structure of joint tissues, summarize key procedures in 3D bioprinting for cartilage repair, and propose strategies for constructing joint organoids using 3D bioprinting.

[Stem Cell Research & Therapy] Scientists present a comprehensive overview of diabetic vasculopathy, demonstrating how the interplay of different vascular cell types is critical for the successful modelling of complex disease processes in vitro.

[Cellular & Molecular Immunology] The authors examine the intersection of the HIV and SARS-CoV-2 pandemics. People with HIV are a heterogeneous group that differ in their degree of immune suppression, immune reconstitution, and viral control.

[Life Sciences] This review of both in vivo and clinical studies has revealed a consistent decline in alpha diversity and increased dissimilarity in beta diversity of gut microbiota in comparison to healthy populations, observed during both the acute and post-infection phases of COVID-19.