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Stem Cell Sources from Human Biological Waste Material: A Role for the Umbilical Cord and Dental Pulp Stem Cells for Regenerative Medicine

[Human Cell] Investigators present a critical observation of umbilical cord-MSCs and dental pulp-MSCs by reviewing articles from the last two decades along with other stem cell sources from different biological waste materials.

Harnessing Three-Dimensional (3D) Cell Culture Models for Pulmonary Infections: State of the Art and Future Directions

[Naunyn-Schmiedebergs Archives Of Pharmacology] Mammalian embryonic and induced pluripotent stem cells may display their remarkable self-organizing abilities in 3D culture, and the resulting organoids replicate important structural and functional characteristics of organs such the kidney, lung, gut, brain, and retina.

Epigenetic Regulation and Therapeutic Targets in the Tumor Microenvironment

[Molecular Biomedicine] The authors focus on the mechanisms of epigenetic modifications occurring to the pivotal tumor microenvironment (TME) components including the stroma, immune and myeloid cells in various tumors reported in the last five years, concluding the tight correlation between TME reprogramming and tumor progression and immunosuppression.

Current Treatment Strategies for EGFR-Mutated Non-Small Cell Lung Cancer: From First Line to Beyond Osimertinib Resistance

[Japanese Journal Of Clinical Oncology] The authors describe current pharmacotherapeutic strategies for epidermal growth factor receptor (EGFR)-mutated NSCLC based on the results of clinical trials and the latest published data.

SARS-CoV-2 and the Nervous System: Current Perspectives

[Archives of Virology] The authors discuss literature focusing on clinical observations that suggest associations between SARS-CoV-2 infection and the nervous system.

Non-Lethal Outcomes of Engaging Regulated Cell Death Pathways in Cancer

[Nature Cancer] Regulated cell death (RCD) is essential for successful systemic cancer therapy. Cells which survive RCD pathways harbor important functions, which can be exploited by cancer cells to promote their own survival and growth, with challenges and opportunities for cancer therapy.

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