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Nanoparticles in Pancreatic Cancer Therapy: A Detailed and Elaborated Review on Patent Literature

[Expert Opinion On Therapeutic Patents] Investigators cover all the major nanotechnology-based patent litrature available on renowned patent data bases like Patentscope and Espacenet, through the time period of 2007-2022.

Application of Patient-Derived Induced Pluripotent Stem Cells and Organoids in Inherited Retinal Diseases

[Current Stem Cell Research & Therapy] Investigators focuse on the status of patient-derived iPSCs and organoids in inherited retinal diseases in recent years concerning disease modeling and therapeutic exploration, along with potential challenges for translating laboratory research to clinical application.

Ketamine and the Neurobiology of Depression: Toward Next-Generation Rapid-Acting Antidepressant Treatments

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Scientists consider what the field has learned from studies of ketamine and to suggest future directions for the optimization of rapid-acting antidepressant treatment.

Bidirectional Interplay between Metabolism and Epigenetics in Hematopoietic Stem Cells and Leukemia

[EMBO Journal] The authors provide an in-depth review of the metabolic and epigenetic interplay regulating hematopoietic stem cell fate, and discuss the influence of metabolic stress stimuli, as well as alterations occurring during leukemic development.

Molecular Monitoring of Lung Allograft Health: Is It Ready for Routine Clinical Use?

[European Respiratory Review] The authors look at the current evidence behind molecular monitoring in lung transplantation and ask if it is ready for routine clinical use.

Hallmarks of Aging in Human Skeletal Muscle and Implications for Understanding the Pathophysiology of Sarcopenia in Women and Men

[Clinical Science] Scientists evaluate how the nine classic hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication contribute to skeletal muscle aging and the pathophysiology of sarcopenia.

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