Publication

[Journal Of Immunotherapy of Cancer] Impaired tumor antigen HER2-specific recognition and immune response of senescent denderitic cells (DC) induced by γδ Treg cells were explored in vitro and in vivo in humanized mouse models. In addition, the DC-based HER2 tumor vaccine immunotherapy in breast cancer models was performed to explore the enhanced antitumor immunity via prevention of DC senescence through blockages of STAT3 and PD-L1 signaling.

[Nature Communications] Treatment of Il12b-/-Il2ra-/- mice mice with PD-1-targeting CAR-T cells selectively depleted liver CD8+ memory T (Trm) cells and alleviated autoimmune cholangitis. Our work highlights the pathogenic role of CD8+ Trm cells and the potential therapeutic usage of PD-1-targeting CAR-T cells.

[Cell Death & Disease] The authors reported that polymerase theta (POLQ), a widely conserved DNA polymerase, positively regulated stem cell-like characteristics of gastric cancer (GC) cells. Knockdown of POLQ suppressed the stemness of GC cells in vitro and in vivo.

[Nature Communications] Scientists performed single-cell RNA-seq and lineage tracing experiments and demonstrated that transient activation of p53 was required to properly reprogram damaged epithelial cells in response to severe radiation injury to promote tissue regeneration.

[Drug Metabolism And Disposition] Researchers demonstrated that up-regulation of YY1 expression was closely associated with breast cancer metastasis, and that high YY1 expression could promote the migratory invasive ability of breast cancer cells.

[Advanced Healthcare Materials] The authors introduced a double-network conductive eutectogel, simulating the conductivity and mechanical strength of natural human skin. When combined with exogenous electrical stimulation, the conductive eutectogel exhibited the ability to reduce inflammation, stimulate cell proliferation and migration, promote collagen deposition and angiogenesis, and facilitate skin tissue remodeling.