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Platelets Mediate the Clearance of Senescent Red Blood Cells by Forming Pro-Phagocytic Platelet-Cell Complexes

[Blood] Pulse-chase labelling studies in mice revealed an approximately ten-fold increase in platelet-red blood cell complexes in the most chronologically aged red blood cell population, compared to younger cells.

Temporal Evolution Reveals Bifurcated Lineages in Aggressive Neuroendocrine Small Cell Prostate Cancer Trans-Differentiation

[Cancer Cell] Scientists performed a multi-omics time course analysis of a pan-small cell neuroendocrine cancer model, a forward genetic transformation using human prostate basal cells and identified a shared developmental, arc-like, and entropy-high trajectory among all transformation model replicates.

MYC-Driven Increases in Mitochondrial DNA Copy Number Occur Early and Persist throughout Prostatic Cancer Progression

[JCI Insight] The authors developed a multiplex in situ method to spatially quantify cell type specific mitochondrial DNA copy number, and showed that it was increased in luminal cells of high-grade prostatic intraepithelial neoplasia and in prostatic adenocarcinomas, and was further elevated in metastatic castration-resistant prostate cancer.

Photothermal Performance of a Novel Carbon Dot and Its Conjugate with Disulfiram for Prostate Cancer PC3 Cell Therapy

[Nanomedicine] Copper, sulfur, nitrogen–carbon quantum dot nanoparticles loaded with the chemotherapy drug disulfiram were tested on the prostate cancer cell line PC3.

NOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and Differentiation

[Development] Using trophoblast stem cells, trophoblast organoids, and primary cytotrophoblasts of early pregnancy, scientists showed that autocrine NOTCH3 signaling controlled human placental expansion and differentiation.

Rapid Intrafibrillar Mineralization Strategy Enhances Adhesive–Dentin Interface

[Journal Of Dental Research] A prebonding rapid intrafibrillar mineralization strategy was developed. Endogenous matrix metalloproteinases as well as exogenous bacterial erosion were inhibited, thus reducing the degradation of dentin collagen.

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