Publication

[Cell Reports] Mechanistically, activated keratinocytes produced chemokines and cytokines that triggered neutrophil chemotaxis and activation in a fatty acid binding protein 5 (FABP5)-dependent manner.

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Abrogation of Ataxia-telangiectasia mutated (ATM) kinase inhibitors expression in melanoma cells via CRISPR-mediated gene knockout reduced 3D invasion in vitro as well as spontaneous lymph node metastasis in vivo.

[Journal Of Clinical Investigation] Germline inheritance of the adrenally permissive allele confers worse outcomes in men with advanced prostate cancer. Scientists investigated whether HSD3B1 (1245C) drove resistance to combined androgen deprivation and radiotherapy.

[Journal Of Clinical Investigation] Studies revealed that six-transmembrane epithelial antigen of prostate-2 (STEAP2) was a prevalent prostate cancer antigen that displayed high, homogeneous cell surface expression across all stages of disease with limited distal normal tissue expression.

[Science Translational Medicine] Researchers identified that deletion of DNA methyltransferases genes decreased expression of neuroendocrine lineage markers and substantially reduced neuroendocrine prostate cancer tumor development and metastasis in vivo.

[Cell & Bioscience] The authors explored the role of Ribonucleotide reductase subunit M2 (RRM2), a gene associated with senescence, in the sensitivity of prostate cancer to docetaxel.