Publication

[Cell Reports] Using a ligand-controlled and pancreas-specific knockout in adult mice, researchers demonstrated that Janus tyrosine kinase (JAK1) deficiency prevented the formation of KRASG12D-induced pancreatic tumors. They established that JAK1 was essential for the constitutive activation of STAT3, whose activation is a prominent characteristic of PDAC.

[Cellular & Molecular Immunology] Scientists employed single-cell RNA sequencing and substrate citrullination mapping to decipher the role of peptidyl arginine deiminase 4 (PAD4) in intestinal inflammation associated with inflammatory bowel disease.

[Cell Death Discovery] Immunofluorescence-staining corroborated salidroside’s capacity to stimulate nerve regeneration and remyelination, suppress glial scar hyperplasia, reduce the activation of neurotoxic A1 astrocytes, and facilitate neural stem cells migration towards the injured region.

[Cell Death & Differentiation] Deficiency of Irg1 or depletion of neuronal Irg1 in striatal neurons was shown to exaggerate neuronal loss and behavioral dysfunction in an intracerebral hemorrhage (ICH) mouse model using transgenic mice.

[Scientific Reports] Scientists combined an additional anti-HIV-1 therapy, which is C46, a cell membrane-anchored HIV-1 fusion inhibitor with the CRISPR/Cas9 mediated knockout CCR5.

[Immunology] Using live cell imaging, researchers found that CD4− iNKT cells limited growth of CD1d+ Epstein–Barr virus (EBV)-infected B-lymphoblastoid spheroids in vitro, whereas CD4+ iNKT cells showed little or no direct anti-tumor activity.