Review

[Nature Reviews Molecular Cell Biology] The authors discuss the molecular mechanisms that regulate RIPK1 to maintain homeostasis and cellular survival in healthy cells, yet drive cell death in a context-dependent manner.

[Immunity] Scientists address how the gut microbiota can profoundly influence neural and immune networks. Although many of the interactions between these three systems originate in the intestinal mucosa, intestinal function and immunity are modulated by neural pathways that connect the gut and brain.

[Ecotoxicology And Environmental Safety] The authors summarize current knowledge on the effects of PAHs and their metabolites on pregnancy and birth outcomes and on placental trophoblast cells.

[Trends In Cancer] Investigators describe mechanisms of action for anti-cancer therapies and mechanotransduction programs that regulate cellular processes, including cell proliferation, apoptosis, survival and phenotype switching.

[Nature Cardiovascular Research] Scientists highlight approaches to examine ECM mechanics at tissue and cellular levels, focusing on how mechanical interactions between cells and the ECM regulate vascular phenotype, especially under certain pathological conditions.

[Experimental Hematology & Oncology] Scientists focus on recent advances in the application of organoids in cancer research and discuss the opportunities and challenges facing organoid research.