Review

[American Journal Of Physiology-Cell Physiology] Scientists summarize new work linking the ECM with circadian clocks and tissue ageing. They discuss how the changes in the biomechanical and biochemical properties of ECM during ageing may contribute to circadian clock dysregulation.

[Signal Transduction And Targeted Therapy] Scientists discuss advancements in the understanding of JAK-STAT–related pathogenic mechanisms; targeted JAK-STAT therapies for various diseases, especially immune disorders, and cancers; newly developed JAK inhibitors; and current challenges and directions in the field.

[Nature Reviews Immunology] The authors review the intertwined nature of T cell differentiation state, location, survival and function, and explain how dysfunctional T cell populations can adopt features of tissue-resident memory T cells to persist in tumors.

[Seminars In Cancer Biology] The authors provide an overview of PDAC, pancreatic stellate cells and their interactions with cancer cells, as well as the currently known role of extracellular vesicles derived from pancreatic stellate cells in PDAC progression.

[Advanced Biology] Investigators look into the interrelationship between COVID-19 and diabetes mellitus with the aim to provide mechanistic insights into the process by which SARS-CoV-2 infects the pancreas and mediates dysfunction and death of endocrine islets.

[International Journal Of Antimicrobial Agents] The authors review the most recent management strategies for Cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients.