Scientists report that transfected small interfering RNAs are not only able to enter the matrix of mitochondria, but also function there to specifically silence targeted mitochondrial transcripts.
[zotpress userid=’1254621′ items=’P7HQZX92′ style=’apa’ cite=’yes’]
Investigators highlight the bidirectional communication of glioma cells and tumor-associated immune cells, the inflammatory mediators enabling leukocytes and transplantable MSC migration, and review preclinical and human clinical trials using MSCs as delivery vehicles.
[Mayo Clinic Proceedings]
Scientists provide an overview of the current basic knowledge of the molecular biology of coronaviruses, which is important as basic knowledge for the development of coronavirus countermeasures.
The authors explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.
Scientists describe recent advances in organoid technologies and their application to cancer biology, clinical translation and precision medicine.
[zotpress userid=’6445218′ items=’46E9YJYE’ style=’apa’ cite=’yes’]
Scientists provide an overview of the role of astrocytes in CNS inflammation, highlighting recent discoveries on astrocyte subsets and the mechanisms that control them.
[Trends in Immunology]
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The authors discuss how to bridge transcriptional states to specific functions so we can develop therapies to mediate negative effects of altered microglia–astrocyte interactions.
[Trends in Immunology]
[zotpress userid=’6445218′ items=’HPITIF9M’ style=’apa’ cite=’yes’]
The authors summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both MAPK and AMPK as a novel therapeutic intervention.
[Journal of Hematology & Oncology]
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Several strategies have been proposed to specifically target cancer stem cells (CSCs) such as the use of CSC‐specific antibodies, small molecules able to target CSCs signaling pathways or drugs able to induce CSCs differentiation rendering them sensitive to classical chemotherapy. These latter compounds are the focus of the present review that aims at reporting recent advances in anticancer differentiation strategy.
[zotpress userid=’1254621′ items=’4PMC3J2J’ style=’apa’ cite=’yes’]
The authors focus on the current state of the most promising non‐viral gene delivery techniques, including electroporation and transfection with cationic polymers or lipids.
[zotpress userid=’1254621′ items=’N6YUT75H’ style=’apa’ cite=’yes’]
The authors discuss recent developments in T2R biology and their role in cellular physiology and expand on the therapeutic potential of T2R agonists in treatment of asthma.
[Current Opinion in Pharmacology]
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