Active RNA Interference in Mitochondria

Scientists report that transfected small interfering RNAs are not only able to enter the matrix of mitochondria, but also function there to specifically silence targeted mitochondrial transcripts.
[Cell Research]
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Inflammatory Mediators in Glioma Microenvironment Play a Dual Role in Gliomagenesis and Mesenchymal Stem Cell Homing: Implication for Cellular Therapy

Investigators highlight the bidirectional communication of glioma cells and tumor-associated immune cells, the inflammatory mediators enabling leukocytes and transplantable MSC migration, and review preclinical and human clinical trials using MSCs as delivery vehicles.
[Mayo Clinic Proceedings]
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Molecular Biology of Coronaviruses: Current Knowledge

Scientists provide an overview of the current basic knowledge of the molecular biology of coronaviruses, which is important as basic knowledge for the development of coronavirus countermeasures.
[Heliyon]
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Animal and Translational Models of SARS-CoV-2 Infection and COVID-19

The authors explore and discuss the diverse animal, cell and tissue models that are being used and developed and collectively recapitulate many critical aspects of disease manifestation in humans to develop and test new preventions and treatments.
[Mucosal Immunology]
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Applications of Organoids for Cancer Biology and Precision Medicine

Scientists describe recent advances in organoid technologies and their application to cancer biology, clinical translation and precision medicine.
[Nature Cancer]
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The Role of Astrocytes in CNS Inflammation

Scientists provide an overview of the role of astrocytes in CNS inflammation, highlighting recent discoveries on astrocyte subsets and the mechanisms that control them.
[Trends in Immunology]
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Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

The authors discuss how to bridge transcriptional states to specific functions so we can develop therapies to mediate negative effects of altered microglia–astrocyte interactions.
[Trends in Immunology]
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The MAPK and AMPK Signalings: Interplay and Implication in Targeted Cancer Therapy

The authors summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both MAPK and AMPK as a novel therapeutic intervention.
[Journal of Hematology & Oncology]
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Differentiation of Cancer Stem Cells Using Synthetic Small Molecules: Toward New Therapeutic Strategies against Therapy Resistance

Several strategies have been proposed to specifically target cancer stem cells (CSCs) such as the use of CSC‐specific antibodies, small molecules able to target CSCs signaling pathways or drugs able to induce CSCs differentiation rendering them sensitive to classical chemotherapy. These latter compounds are the focus of the present review that aims at reporting recent advances in anticancer differentiation strategy.
[Chemmedchem]
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Optimization of Electroporation and other Non‐Viral Gene Delivery Strategies for T Cells

The authors focus on the current state of the most promising non‐viral gene delivery techniques, including electroporation and transfection with cationic polymers or lipids.
[Biotechnology Progress]
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Therapeutic Potential and Challenges of Bitter Taste Receptors on Lung Cells

The authors discuss recent developments in T2R biology and their role in cellular physiology and expand on the therapeutic potential of T2R agonists in treatment of asthma.
[Current Opinion in Pharmacology]
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