Review

[Acta Neuropathologica] Scientists summarize the current understanding of the sources and fates of resident CNS-associated macrophages in health and disease, and the role of the microenvironment in influencing their maintenance and function.

[Immunity] The authors discuss the distinct functions of LAG-3, TIM-3, and TIGIT, including their contributions to the regulation of immune cells beyond T cells, their roles in disease, and the implications for their targeting in the clinic.

[Oncogene] The authors present an overview of the current progress in understanding of cellular heterogeneity and tumor origin of medulloblastoma and discuss novel findings in the age of single-cell technologies.

[Inflammation Research] The authors highlight critical aspects of intestinal organoids in IBD, such as their potential applications, viability, cell renewal ability, and barrier functionality.

[Journal Of Molecular And Cellular Cardiology] Transplantation of hPSC-cardiomyocytes (CMs) into the myocardium of large animals in a myocardial infarction model improved cardiac function. The engrafted hPSC-CMs matured, and microvessels derived from the host entered the graft abundantly.

[Immunology] Scientists provide an overview of studies on changes in plasma milieu and discusses recent findings linking plasma factors to T cell and monocyte/macrophage pathology in pulmonary tuberculosis patients.