Wnt/β-catenin

[Proceedings of the National Academy of Sciences of the United States of America] The authors showed in mouse embryonic ovaries that germ cell–intrinsic β-catenin activity maintained pluripotency and that its repression was essential to allow differentiation and meiosis entry in a timely manner.

[Oncogene] Researchers found that miR-22 facilitated β-catenin stabilization through directly repressing citrullinase PAD2.

[Cell Reports] Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.

[Biochemical and Biophysical Research Communications] The relevance of pleckstrin homology-like domain family A, member 3 (PHLDA3) in prostate cancer has not been explored. Scientists illustrated the possible roles and mechanisms of PHLDA3 in prostate cancer.

[Scientific Reports] Scientists investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms.

[Journal of Leukocyte Biology] The authors suggest that proteomic profiles at the early stage of chronic lymphocytic leukemia (CLL) can discriminate progressive from stable disease and that RNA splicing dysregulation underlies CLL evolution, which opens new perspectives in terms of biomarkers and therapy.