Identification of Cis-HOX-HOXC10 Axis as a Therapeutic Target for Colorectal Tumor-Initiating Cells without APC Mutations

Circular RNA stabilizing HOXC10 (cis-HOX) was robustly expressed in colorectal tumor-initiating cells (TICs). cis-HOX knockout decreased colorectal TIC numbers and impaired the self-renewal, tumorigenesis, and metastatic capacities of TICs, whereas cis-HOX overexpression drove colorectal TIC self-renewal and metastasis.