To further evaluate the role of UBASH3A in type 1 diabetes, scientists targeted Ubash3a in NOD mice using zinc-finger nuclease mediated mutagenesis.
[Scientific Reports]
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Chen, Y.-G., Ciecko, A. E., Khaja, S., Grzybowski, M., Geurts, A. M., & Lieberman, S. M. (2020). UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Scientific Reports, 10(1), 12019. https://doi.org/10.1038/s41598-020-68956-6 Cite