Angiogenesis and β‐cell expansion in the pancreas were coupled by a distinct age‐dependent subset of endothelial cells (ECs). While this EC subpopulation supported pancreatic β cells, it declined during aging concomitant with increased expression of the gap junction protein Gja1.
[EMBO Journal]
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Chen, J., Lippo, L., Labella, R., Tan, S. L., Marsden, B. D., Dustin, M. L., Ramasamy, S. K., & Kusumbe, A. P. (2020). Decreased blood vessel density and endothelial cell subset dynamics during ageing of the endocrine system. The EMBO Journal, n/a(n/a), e105242. https://doi.org/10.15252/embj.2020105242 Cite