Investigators review the clinical presentations of cutaneous immune‐related adverse effects associated with checkpoint inhibitor therapy in adult patients with metastatic malignant melanoma.
[British Journal of Dermatology]
6807162 {6807162:7BG42A5L} apa 50 1 157450 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-089e828470e6bc1f347b3881e22c4f78%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%227BG42A5L%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Gault%20et%20al.%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EGault%2C%20A.%2C%20Anderson%2C%20A.%20E.%2C%20Plummer%2C%20R.%2C%20Stewart%2C%20C.%2C%20Pratt%2C%20A.%20G.%2C%20%26amp%3B%20Rajan%2C%20N.%20%28n.d.%29.%20Cutaneous%20immune-related%20adverse%20events%20in%20patients%20with%20melanoma%20treated%20with%20checkpoint%20inhibitors.%20%3Ci%3EBritish%20Journal%20of%20Dermatology%3C%5C%2Fi%3E%2C%20%3Ci%3En%5C%2Fa%3C%5C%2Fi%3E%28n%5C%2Fa%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbjd.19750%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2Fhttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbjd.19750%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3D7BG42A5L%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Cutaneous%20immune-related%20adverse%20events%20in%20patients%20with%20melanoma%20treated%20with%20checkpoint%20inhibitors%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%22%2C%22lastName%22%3A%22Gault%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20E.%22%2C%22lastName%22%3A%22Anderson%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22R.%22%2C%22lastName%22%3A%22Plummer%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C.%22%2C%22lastName%22%3A%22Stewart%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22A.%20G.%22%2C%22lastName%22%3A%22Pratt%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22N.%22%2C%22lastName%22%3A%22Rajan%22%7D%5D%2C%22abstractNote%22%3A%22Checkpoint%20inhibitor%20%28CPI%29%20therapy%20has%20vastly%20improved%20long-term%20outcomes%20in%20metastatic%20malignant%20melanoma%20%28MMM%29.%20Therapy%20takes%20the%20form%20of%20monoclonal%20antibody%20infusions%20that%20target%20immune%20cell%20checkpoint%20proteins%2C%20such%20as%20cytotoxic%20T-lymphocyte-associated%20protein%204%20%28CTLA4%29%20and%20programmed%20death%201%5C%2Fprogrammed%20death%20ligand%201%20%28PD1%5C%2FPDL1%29.%20Cutaneous%20immune-related%20adverse%20effects%20%28IrAEs%29%20are%20frequent%20in%20patients%20with%20MMM%20treated%20with%20CPIs.%20Our%20aim%20was%20to%20review%20the%20clinical%20presentations%20of%20cutaneous%20IrAEs%20associated%20with%20CPI%20therapy%20in%20adult%20patients%20with%20MMM.%20We%20carried%20out%20a%20literature%20review%20of%20clinical%20trials%2C%20case%20series%20and%20case%20reports%20of%20patients%20with%20melanoma%20and%20those%20with%20other%20cancers%20treated%20with%20anti-CTLA4%2C%20anti-PD1%5C%2FPDL1%2C%20or%20a%20combination%20of%20these%20therapies.%20Diverse%20clinical%20presentations%20of%20cutaneous%20IrAEs%20are%20recognized.%20Anti-CTLA4%20therapy%20has%20a%20higher%20associated%20rate%20of%20cutaneous%20IrAEs%20than%20anti-PD1%5C%2FPDL1%20therapies.%20Low-grade%20cutaneous%20IrAEs%20are%20common%20and%20are%20usually%20managed%20supportively%20while%20continuing%20CPI%20therapy.%20Delayed%20presentations%20arising%20after%20established%20use%20of%20CPIs%20can%20make%20therapy-associated%20cutaneous%20IrAEs%20difficult%20to%20distinguish%20from%20coincidental%20dermatological%20disease.%20Vitiligo-like%20depigmentation%20is%20a%20good%20prognostic%20indicator%20of%20outcome%20in%20patients%20with%20melanoma.%20Life-threatening%20adverse%20events%20including%20toxic%20epidermal%20necrolysis%20are%20rare.%20The%20identification%20of%20predictive%20biomarkers%20that%20highlight%20patients%20at%20risk%20of%20life-threatening%20IrAEs%20remains%20an%20unmet%20need.%20The%20involvement%20of%20dermatologists%20in%20the%20multidisciplinary%20assessment%20of%20cutaneous%20IrAEs%20is%20increasingly%20pertinent%20in%20the%20management%20and%20care%20of%20CPI-treated%20patients%20with%20melanoma.%22%2C%22date%22%3A%22%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%22https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1111%5C%2Fbjd.19750%22%2C%22ISSN%22%3A%221365-2133%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fonlinelibrary.wiley.com%5C%2Fdoi%5C%2Fabs%5C%2F10.1111%5C%2Fbjd.19750%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-01-04T18%3A45%3A38Z%22%7D%7D%5D%7D
Gault, A., Anderson, A. E., Plummer, R., Stewart, C., Pratt, A. G., & Rajan, N. (n.d.). Cutaneous immune-related adverse events in patients with melanoma treated with checkpoint inhibitors. British Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjd.19750 Cite