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Pulmonary Cell NewsScientists present three crystal structures of full-length dengue virus NS1 complexed with a flavivirus–cross-reactive, NS1-specific monoclonal antibody, 2B7, at resolutions between 2.89 and 3.96 angstroms. These structures reveal a protective mechanism by which two domains of NS1 are antagonized simultaneously.
[Science]
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Biering, S. B., Akey, D. L., Wong, M. P., Brown, W. C., Lo, N. T. N., Puerta-Guardo, H., Sousa, F. T. G. de, Wang, C., Konwerski, J. R., Espinosa, D. A., Bockhaus, N. J., Glasner, D. R., Li, J., Blanc, S. F., Juan, E. Y., Elledge, S. J., Mina, M. J., Beatty, P. R., Smith, J. L., & Harris, E. (2021). Structural basis for antibody inhibition of flavivirus NS1–triggered endothelial dysfunction. Science, 371(6525), 194–200. https://doi.org/10.1126/science.abc0476 Cite
