MDA-MB-231-cells, iodine nanoparticles, and CD31 were examined by fluorescence confocal microscopy.
[Scientific Reports]
6807162 {6807162:ZBZ2WA5S} apa 50 1 157917 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-0628605be0c52d7a2726a1ca97604296%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22ZBZ2WA5S%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Ridwan%20et%20al.%22%2C%22parsedDate%22%3A%222021-01-13%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3ERidwan%2C%20S.%20M.%2C%20Hainfeld%2C%20J.%20F.%2C%20Ross%2C%20V.%2C%20Stanishevskiy%2C%20Y.%2C%20%26amp%3B%20Smilowitz%2C%20H.%20M.%20%282021%29.%20Novel%20Iodine%20nanoparticles%20target%20vascular%20mimicry%20in%20intracerebral%20triple%20negative%20human%20MDA-MB-231%20breast%20tumors.%20%3Ci%3EScientific%20Reports%3C%5C%2Fi%3E%2C%20%3Ci%3E11%3C%5C%2Fi%3E%281%29%2C%201203.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-80862-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs41598-020-80862-5%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3DZBZ2WA5S%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Novel%20Iodine%20nanoparticles%20target%20vascular%20mimicry%20in%20intracerebral%20triple%20negative%20human%20MDA-MB-231%20breast%20tumors%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sharif%20M.%22%2C%22lastName%22%3A%22Ridwan%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22James%20F.%22%2C%22lastName%22%3A%22Hainfeld%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Vanessa%22%2C%22lastName%22%3A%22Ross%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Yaroslav%22%2C%22lastName%22%3A%22Stanishevskiy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Henry%20M.%22%2C%22lastName%22%3A%22Smilowitz%22%7D%5D%2C%22abstractNote%22%3A%22Triple%20negative%20breast%20cancer%20%28TNBC%29%2C%5Cu2009~%5Cu200910%5Cu201320%25%20of%20diagnosed%20breast%20cancers%2C%20metastasizes%20to%20brain%2C%20lungs%2C%20liver.%20Iodine%20nanoparticle%20%28INP%29%20radioenhancers%20specifically%20localize%20to%20human%20TNBC%20MDA-MB-231%20tumors%20growing%20in%20mouse%20brains%20after%20iv%20injection%2C%20significantly%20extending%20survival%20of%20mice%20after%20radiation%20therapy%20%28RT%29.%20A%20prominent%20rim%20of%20INP%20contrast%20%28MicroCT%29%20previously%20seen%20in%20subcutaneous%20tumors%20but%20not%20intracerebral%20gliomas%2C%20provide%20calculated%20X-ray%20dose-enhancements%20up%20to%5Cu2009%3E%5Cu2009eightfold.%20Here%2C%20MDA-MB-231-cells%2C%20INPs%2C%20CD31%20were%20examined%20by%20fluorescence%20confocal%20microscopy.%20Most%20INP%20staining%20co-localized%20with%20CD31%5Cu00a0in%20the%20tumor%20center%20and%20periphery.%20Greatest%20INP%5C%2FCD31%20staining%20was%20in%20the%20tumor%20periphery%2C%20the%20region%20of%20increased%20MicroCT%20contrast.%20Tumor%20cells%20are%20seen%20to%20line%20irregularly-shaped%20spaces%20%28ISS%29%20with%20INP%2C%20CD31%20staining%20very%20close%20to%20or%20on%20the%20tumor%20cell%20surface%20and%20PAS%20stain%20on%20their%20boundary%20and%20may%20represent%20a%20unique%20form%20of%20CD31-expressing%20vascular%20mimicry%20in%20intracerebral%20231-tumors.%20INP%5C%2FCD31%20co-staining%20is%20also%20seen%20around%20ISS%20formed%20around%20tumor%20cells%20migrating%20on%20CD31%2B%20blood-vessels.%20The%20significant%20radiation%20dose%20enhancement%20to%20the%20prolific%20collagen%20I%20containing%2C%20INP-binding%20ISS%20found%20throughout%20the%20tumor%20but%20concentrated%20in%20the%20tumor%20rim%2C%20may%20contribute%20significantly%20to%20the%20life%20extensions%20observed%20after%20INP-RT%3B%20VM%20could%20represent%20a%20new%20drug%5C%2FNP%2C%20particularly%20INP%2C%20tumor-homing%20target.%22%2C%22date%22%3A%222021-01-13%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs41598-020-80862-5%22%2C%22ISSN%22%3A%222045-2322%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs41598-020-80862-5%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-01-13T23%3A43%3A21Z%22%7D%7D%5D%7D
Ridwan, S. M., Hainfeld, J. F., Ross, V., Stanishevskiy, Y., & Smilowitz, H. M. (2021). Novel Iodine nanoparticles target vascular mimicry in intracerebral triple negative human MDA-MB-231 breast tumors. Scientific Reports, 11(1), 1203. https://doi.org/10.1038/s41598-020-80862-5 Cite