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Pulmonary Cell NewsResearchers showed that KPT-330 prevented, attenuated and mitigated calcific nodule formation in heart valve interstitial cells in vitro, and prevented calcific aortic valve disease in Klotho-/- mice.
[Circulation Research]
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Dutta Punashi, Kodigepalli Madhav Karthik, LaHaye Stephanie, Thompson J Will, Rains Sarah, Nagel Casey, Thatcher Kaitlyn, Hinton Robert B, & Lincoln Joy. (n.d.). KPT-330 Prevents Aortic Valve Calcification via a Novel C/EBPβ Signaling Pathway. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.318503 Cite
