Chromatin Remodeling by the Histone Methyltransferase EZH2 Drives Lung Pre-malignancy and Is a Target for Cancer Prevention

Tobacco carcinogen transformed human bronchial epithelial lines were characterized for cytosine DNA methylation, transcriptome reprogramming, and the effect of inhibiting EZH2 and G9a on the transformed phenotype. The effects of targeting EZH2 and G9a on lung cancer prevention was assessed in the A/J mouse lung tumor model.