Synaptotagmin-1 Interacts with PI(4,5)P2 to Initiate Synaptic Vesicle Docking in Hippocampal Neurons

By
Justin.choi
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Scientists showed that in mouse hippocampal synapses, synaptic vesicle (SV) docking initiates at ∼12 nm to the active zone (AZ) by Synaptotagmin-1 (Syt1). They also demonstrated that PI(4,5)P2 was the membrane partner of Syt1 to initiate SV docking, and disrupting their interaction could abolish the docking initiation.
[Cell Reports]
Chen, Y., Wang, Y.-H., Zheng, Y., Li, M., Wang, B., Wang, Q.-W., Fu, C.-L., Liu, Y.-N., Li, X., & Yao, J. (2021). Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons. Cell Reports, 34(11). https://doi.org/10.1016/j.celrep.2021.108842 Cite
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