Investigators report that bone-borne TGF-β induced the acetylation of transcription factor KLF5 in prostate cancer bone metastases, and acetylated KLF5 caused osteoclastogenesis and bone metastatic lesions by activating CXCR4, which led to IL-11 secretion, and stimulated SHH/IL-6 paracrine signaling.
[Nature Communications]
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