Acetylcholine Ameliorates Colitis by Promoting IL-10 Secretion of Monocytic Myeloid-Derived Suppressor Cells through the nAChR/ERK Pathway

By
Justin.choi
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By using the xCell tool and the latest immunolabeling-enabled 3D imaging of solvent-cleared organs technique, we found severe pathological damage of the entire ENS and decreased expression of choline acetyltransferase in inflammatory bowel disease patients.
[Proceedings of the National Academy of Sciences of the United States of America]
Zheng, W., Song, H., Luo, Z., Wu, H., Chen, L., Wang, Y., Cui, H., Zhang, Y., Wang, B., Li, W., Liu, Y., Zhang, J., Chu, Y., Luo, F., & Liu, J. (2021). Acetylcholine ameliorates colitis by promoting IL-10 secretion of monocytic myeloid-derived suppressor cells through the nAChR/ERK pathway. Proceedings of the National Academy of Sciences, 118(11). https://doi.org/10.1073/pnas.2017762118 Cite
Abstract