NRG1 is a trophic factor that contains an epidermal growth factor-like domain that signals by stimulating ERBB receptor tyrosine kinases and the cytoplasmic domain.
[Biochemical and Biophysical Research Communications]
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Matsuki, M., Inoue, R., Murai, A., Kubo, T., Hashimoto, S., Murata, K., Kanaseki, T., Tsukahara, T., Nishida, S., Tanaka, T., Kitamura, H., Masumori, N., Hirohashi, Y., & Torigoe, T. (2021). Neuregulin-1-β1 and γ-secretase play a critical role in sphere-formation and cell survival of urothelial carcinoma cancer stem-like cells. Biochemical and Biophysical Research Communications, 552, 128–135. https://doi.org/10.1016/j.bbrc.2021.03.038 Cite