Scientists review genome editing approaches aimed either at correcting the disease-causing mutations or at modulating the expression of genetic modifiers, e.g. by repairing SOD1 mutations or SMN2 splicing defect, or deleting C9orf72 expanded repeats.
[Molecular Therapy]
6807162 {6807162:SKKEJNSA} apa 50 1 160933 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/ %7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-eb45424d6e517c481affd820ceb5275c%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22SKKEJNSA%22%2C%22library%22%3A%7B%22id%22%3A6807162%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Miccio%20et%20al.%22%2C%22parsedDate%22%3A%222021-04-03%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EMiccio%2C%20A.%2C%20Antoniou%2C%20P.%2C%20Ciura%2C%20S.%2C%20%26amp%3B%20Kabashi%2C%20E.%20%282021%29.%20Novel%20genome-editing-based%20approaches%20to%20treat%20motor%20neuron%20diseases%3A%20promises%20and%20challenges.%20%3Ci%3EMolecular%20Therapy%3C%5C%2Fi%3E%2C%20%3Ci%3E0%3C%5C%2Fi%3E%280%29.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ymthe.2021.04.003%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1016%5C%2Fj.ymthe.2021.04.003%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6807162%26amp%3Bitem_key%3DSKKEJNSA%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22Novel%20genome-editing-based%20approaches%20to%20treat%20motor%20neuron%20diseases%3A%20promises%20and%20challenges%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Annarita%22%2C%22lastName%22%3A%22Miccio%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Panagiotis%22%2C%22lastName%22%3A%22Antoniou%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sorana%22%2C%22lastName%22%3A%22Ciura%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Edor%22%2C%22lastName%22%3A%22Kabashi%22%7D%5D%2C%22abstractNote%22%3A%22%22%2C%22date%22%3A%222021-04-03%22%2C%22language%22%3A%22English%22%2C%22DOI%22%3A%2210.1016%5C%2Fj.ymthe.2021.04.003%22%2C%22ISSN%22%3A%221525-0016%2C%201525-0024%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.cell.com%5C%2Fmolecular-therapy-family%5C%2Fmolecular-therapy%5C%2Fabstract%5C%2FS1525-0016%2821%2900190-8%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-04-07T18%3A48%3A49Z%22%7D%7D%5D%7DMiccio, A., Antoniou, P., Ciura, S., & Kabashi, E. (2021). Novel genome-editing-based approaches to treat motor neuron diseases: promises and challenges.
Molecular Therapy,
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