The authors report, the astrocyte-derived secreted lipocalin Glial Lazarillo , a homolog of human Apolipoprotein D, and its neuronal receptor, the brain-specific short isoforms of Drosophila lipophorin receptor 1, cooperatively mediated neuron-glia lipid shuttling and support dendrite morphogenesis.
[Nature Communications]
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Yin, J., Spillman, E., Cheng, E. S., Short, J., Chen, Y., Lei, J., Gibbs, M., Rosenthal, J. S., Sheng, C., Chen, Y. X., Veerasammy, K., Choetso, T., Abzalimov, R., Wang, B., Han, C., He, Y., & Yuan, Q. (2021). Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling. Nature Communications, 12(1), 2408. https://doi.org/10.1038/s41467-021-22751-7 Cite