Scientists showed that retinoic acid had a broader role in 2C‐like cells state, not only was one of the upstream regulators of the 2C‐like state in chemically defined media but also illuminated genetic and epigenetic regulations that govern ESCs to 2C‐like transition.
[Cell Proliferation]
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Wang, Y., Na, Q., Li, X., Tee, W.-W., Wu, B., & Bao, S. (n.d.). Retinoic acid induces NELFA-mediated 2C-like state of mouse embryonic stem cells associates with epigenetic modifications and metabolic processes in chemically defined media. Cell Proliferation, n/a(n/a), e13049. https://doi.org/https://doi.org/10.1111/cpr.13049 Cite