Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing

The authors integrated six bead-enriched T cell subsets with 62,235 single-cell transcriptomes from human PBMCs and clustered them into nine scRNA-seq clustered populations.
[Journal of Immunology]
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Blockade of Beta-Adrenergic Receptors Reduces Cancer Growth and Enhances the Response to Anti-CTLA4 Therapy by Modulating the Tumor Microenvironment

Investigators showed that oral administration of propranolol delayed tumor progression of MCA205 fibrosarcoma model and MC38 colon cancer model and increased the survival rate of tumor bearing mice.
[Oncogene]
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Silencing ESRP1 Expression Promotes Caspase-Independent Cell Death via Nuclear Translocation of AIF in Colon Cancer Cells

Scientists analyzed Clinical Proteomic Tumor Analysis Consortium, colon tissue microarray, and colon cancer cells to evaluate the ESRP1 expression levels in colorectal cancer subtypes.
[Cellular Signalling]
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Effect of Duty Cycles of Tumor-Treating Fields on Glioblastoma Cells and Normal Brain Organoids

The authors evaluated the effects of tumor‑treating fields with different duty cycles on glioma spheroid cells and normal brain organoids.
[International Journal of Oncology]
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Myeloid Ikaros–SIRT1 Signaling Axis Regulates Hepatic Inflammation and Pyroptosis in Ischemia-Stressed Mouse and Human Liver

Investigators undertook molecular and functional studies to interrogate the significance of the myeloid Ikaros–SIRT1 axis in the innate immune activation and to determine whether it served as a homeostatic sentinel in hepatic rejuvenation in mouse and human liver.
[Journal of Hepatology]
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Mouse Organoid Culture Is a Suitable Model to Study Esophageal Ion Transport Mechanisms

Scientists generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs.
[American Journal of Physiology-Cell Physiology]
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Chronic Mineral Oil Administration Increases Hepatic Inflammation in Wild Type Mice Compared to Lipocalin 2 Null Mice

Scientists investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.
[Laboratory Investigation]
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Generation of Multipotential NG2 Progenitors from Mouse Embryonic Stem Cell-Derived Neural Stem Cells

Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.
[Frontiers in Cell and Developmental Biology]
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New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells

For the purpose of easy monitoring of differentiation efficiencies into pancreatic progenitors and insulin-producing cells, scientists generated new reporter lines by knocking in a P2A-H-2Kk-F2A-GFP2 reporter gene into the SOX9-locus and a P2A-mCherry reporter gene into the INS-locus mediated by CRISPR/CAS9-technology.
[Stem Cell Reviews and Reports]
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CD8+ Tissue-Resident Memory T Cells Promote Liver Fibrosis Resolution by Inducing Apoptosis of Hepatic Stellate Cells

Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.
[Nature Communications]
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Circulating Tumor Cell Copy-Number Heterogeneity in ALK-Rearranged Non-Small-Cell Lung Cancer Resistant to ALK Inhibitors

Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.
[npj Precision Oncology]
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