Scientists generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs.
[American Journal of Physiology-Cell Physiology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Scientists investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.
[Frontiers in Cell and Developmental Biology]
[zotpress userid=” items=’GF3UFAS2′ style=’apa’ cite=’yes’]
For the purpose of easy monitoring of differentiation efficiencies into pancreatic progenitors and insulin-producing cells, scientists generated new reporter lines by knocking in a P2A-H-2Kk-F2A-GFP2 reporter gene into the SOX9-locus and a P2A-mCherry reporter gene into the INS-locus mediated by CRISPR/CAS9-technology.
[Stem Cell Reviews and Reports]
[zotpress userid=’7992332′ items=’9KVS8U2E’ style=’apa’ cite=’yes’]
Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103−CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.
[zotpress userid=” items=’TGCNFWJ4′ style=’apa’ cite=’yes’]
Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.
[npj Precision Oncology]
[zotpress userid=” items=’44S6796E’ style=’apa’ cite=’yes’]
The authors investigated mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in glial pathobiology across species and models.
[zotpress userid=’7992332′ items=’7D4R3M5K’ style=’apa’ cite=’yes’]
Investigators demonstrated that their robust, patient-derived xenograft (PDX) model for myelodysplastic syndrome was applicable as a preclinical platform to address pending clinical questions by interrogating the efficacy and safety of the thrombopoietin receptor agonist eltrombopag.
[zotpress userid=’7992332′ items=’88ABE4IK’ style=’apa’ cite=’yes’]
Researchers investigated molecular mechanisms underlying circular RNA AFF4-regulated Bone marrow-derived-MSCs osteogenesis.
[Cell Death & Disease]
[zotpress userid=” items=’PEFG9JRJ’ style=’apa’ cite=’yes’]
The authors described their development of cell culture techniques for the enrichment of functional hematopoietic stem and progenitor cells from mouse bone marrow without the use of fluorescence-activated cell sorting purification.
[zotpress userid=” items=’ZC8LAPZS’ style=’apa’ cite=’yes’]
Scientists showed that retinoic acid had a broader role in 2C‐like cells state, not only was one of the upstream regulators of the 2C‐like state in chemically defined media but also illuminated genetic and epigenetic regulations that govern ESCs to 2C‐like transition.
[zotpress userid=’6606345′ items=’JV86RJGW’ style=’apa’ cite=’yes’]