Mouse Organoid Culture Is a Suitable Model to Study Esophageal Ion Transport Mechanisms

Scientists generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs.
[American Journal of Physiology-Cell Physiology]
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Chronic Mineral Oil Administration Increases Hepatic Inflammation in Wild Type Mice Compared to Lipocalin 2 Null Mice

Scientists investigated the roles of Lipocalin 2 (LCN2) in chronic inflammation and fibrosis, using repeated carbon tetrachloride in mineral-oil injection. Hepatic and serum LCN2 levels were remarkably higher in the mineral oil-injected wild type group compared to the CCl4.
[Laboratory Investigation]
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Generation of Multipotential NG2 Progenitors from Mouse Embryonic Stem Cell-Derived Neural Stem Cells

Research developed a simple method to generate homogeneous immature oligodendrocyte lineage cells from mouse embryonic stem cells-derived neural stem cell.
[Frontiers in Cell and Developmental Biology]
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New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells

For the purpose of easy monitoring of differentiation efficiencies into pancreatic progenitors and insulin-producing cells, scientists generated new reporter lines by knocking in a P2A-H-2Kk-F2A-GFP2 reporter gene into the SOX9-locus and a P2A-mCherry reporter gene into the INS-locus mediated by CRISPR/CAS9-technology.
[Stem Cell Reviews and Reports]
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CD8+ Tissue-Resident Memory T Cells Promote Liver Fibrosis Resolution by Inducing Apoptosis of Hepatic Stellate Cells

Single-cell transcriptome analysis and FACS analysis revealed CD69+CD103CD8+ Trm cell enrichment in non-alcoholic steatohepatitis resolution livers.
[Nature Communications]
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Circulating Tumor Cell Copy-Number Heterogeneity in ALK-Rearranged Non-Small-Cell Lung Cancer Resistant to ALK Inhibitors

Researchers provided in-depth investigation of copy number alteration heterogeneity in phenotypically characterized circulating tumor cells at resistance to Anaplastic Lymphoma Kinase (ALK)-tyrosine kinase inhibitors in ALK-positive non-small cell lung cancer.
[npj Precision Oncology]
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Cell-Intrinsic Glial Pathology Is Conserved across Human and Murine Models of Huntington’s Disease

The authors investigated mutant HTT-associated changes in gene expression by mouse and human striatal astrocytes, as well as in mouse microglia, to identify commonalities in glial pathobiology across species and models.
[Cell Reports]
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Preclinical Evaluation of Eltrombopag in a PDX Model of Myelodysplastic Syndromes

Investigators demonstrated that their robust, patient-derived xenograft (PDX) model for myelodysplastic syndrome was applicable as a preclinical platform to address pending clinical questions by interrogating the efficacy and safety of the thrombopoietin receptor agonist eltrombopag.
[Leukemia]
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Circular RNA AFF4 Modulates Osteogenic Differentiation in BM-MSCs by Activating SMAD1/5 Pathway through miR-135a-5p/FNDC5/Irisin Axis

Researchers investigated molecular mechanisms underlying circular RNA AFF4-regulated Bone marrow-derived-MSCs osteogenesis.
[Cell Death & Disease]
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Non-Conditioned Bone Marrow Chimeric Mouse Generation Using Culture-Based Enrichment of Hematopoietic Stem and Progenitor Cells

The authors described their development of cell culture techniques for the enrichment of functional hematopoietic stem and progenitor cells from mouse bone marrow without the use of fluorescence-activated cell sorting purification.
[Nature Communications]
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Retinoic Acid Induces NELFA‐Mediated 2C‐like State of Mouse Embryonic Stem Cells Associates with Epigenetic Modifications and Metabolic Processes in Chemically Defined Media

Scientists showed that retinoic acid had a broader role in 2C‐like cells state, not only was one of the upstream regulators of the 2C‐like state in chemically defined media but also illuminated genetic and epigenetic regulations that govern ESCs to 2C‐like transition.
[Cell Proliferation]
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