Hotspot DNMT3A Mutations in Clonal Hematopoiesis and Acute Myeloid Leukemia Sensitize Cells to Azacytidine via Viral Mimicry Response

Researchers demonstrated that DNA methyltransferase 3A (DNMT3AR882H)-dependent clonal hematopoiesis and acute myeloid leukemia cells are specifically susceptible to the hypomethylating agent azacytidine.