Cell-Type-Specific Effects of Genetic Variation on Chromatin Accessibility during Human Neuronal Differentiation

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Researchers identified significant genetic effects on 988/1,839 neuron/progenitor regulatory elements, with highly cell-type and temporally specific effects.
[Nature Neuroscience]
Liang, D., Elwell, A. L., Aygün, N., Krupa, O., Wolter, J. M., Kyere, F. A., Lafferty, M. J., Cheek, K. E., Courtney, K. P., Yusupova, M., Garrett, M. E., Ashley-Koch, A., Crawford, G. E., Love, M. I., de la Torre-Ubieta, L., Geschwind, D. H., & Stein, J. L. (2021). Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation. Nature Neuroscience, 1–13. https://doi.org/10.1038/s41593-021-00858-w Cite
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