Using Syrian hamsters that modeled moderate to severe COVID-19 disease, the authors demonstrated the high efficacy of PiN-21 to prevent and treat SARS-CoV-2 infection.
[Science Advances]
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Nambulli, S., Xiang, Y., Tilston-Lunel, N. L., Rennick, L. J., Sang, Z., Klimstra, W. B., Reed, D. S., Crossland, N. A., Shi, Y., & Duprex, W. P. (2021). Inhalable Nanobody (PiN-21) prevents and treats SARS-CoV-2 infections in Syrian hamsters at ultra-low doses. Science Advances, 7(22), eabh0319. https://doi.org/10.1126/sciadv.abh0319 Cite