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Pulmonary Cell NewsScientists showed that the translation inhibition activity of NSP14 was conserved in human coronaviruses. NSP14 was required for virus replication through contribution of its exoribonuclease and N7-methyltransferase activities.
[Proceedings of the National Academy of Sciences of the United States of America]
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Hsu, J. C.-C., Laurent-Rolle, M., Pawlak, J. B., Wilen, C. B., & Cresswell, P. (2021). Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein. Proceedings of the National Academy of Sciences, 118(24). https://doi.org/10.1073/pnas.2101161118 Cite
