HTR1A Antagonist Enhances GnRH Transcription via PRC1 Complex Degradation and H2AK119ub Loss Driven by Reduced CBX4 Expression through PI3K/Akt Pathway Suppression in GnRH Neurons for Pubertal Initiation Control

0
412
The upregulated gonadotropin-releasing hormone (GnRH) expression in GT1-7 GnRH neuronal cells induced by the 5-HT receptor 1A (HTR1A) antagonist WAY-100635 maleate was observed in vitro.
[Molecular Therapy-Nucleic Acids]
AbstractFull ArticleGraphical Abstract