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Pulmonary Cell NewsThe authors report ed cryo-EM structures of both trimeric spike ectodomains in complex with the 47D11 Fab. 47D11 bound to the closed receptor-binding domain, distal to the ACE2 binding site.
[Science Advances]
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Fedry, J., Hurdiss, D. L., Wang, C., Li, W., Obal, G., Drulyte, I., Du, W., Howes, S. C., Kuppeveld, F. J. M. van, Förster, F., & Bosch, B.-J. (2021). Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11. Science Advances, 7(23), eabf5632. https://doi.org/10.1126/sciadv.abf5632 Cite
